Doc. Dr. Daria Ler

Doc. Dr. Daria Ler - Dijagnostičko odjeljenje

Doc. Dr. Daria Ler

Rođen(a):

Molekularni genetičar

PhD in molecular biology and genetics, University of Sarajevo, Bosnia and Herzegovina, 2011.  

MSc in molecular microbiology at Karl-Franzens University Graz, Austria, 2007. 

BSc in molecular biology at Karl-Franzens University Graz, Austria, 2006.

Mandatory preparation programe of german language at Karl-Franzens University Graz, Austria, 2000.

 

2014 Oct - present: Chief of laboratory for Molecular Diagnostics at PZU “Moja Klinika” and assistant professor at Department of Genetics and Bioengineering, International University of Sarajevo (IUS) - expert in praxis

2014: Head of Department for Natural Sciences and Program Coordinator of Genetics and Bioengineering Program at IUS.

2012- 2014: Assist. Prof. Dr. at International University of Sarajevo (IUS), Genetics and Bioengineering Program.

2010 - 2012: Senior Assistant at International University of Sarajevo (IUS), Genetics and Bioengineering Program.  

2008 - 2010: Teaching Assistant and Student Advisor, Genetics and Bioengineering Program, IUS.  

2009: Guest researcher at University Clinic Hamburg - Eppendorf (UKE), Hamburg, Germany. 

2008: Assistant Coordinator of the 5th World Water Forum – Regional Process, April 2008, Sarajevo, Bosnia and Herzegovina. 

2006 – 2007:  Research Assistant at Clinical Oncology Laboratory - Center for Basic Medical Research, Institute for Internal Medicine, Department of Oncology, National Clinic in Graz, Austria (ZMF-LKH Graz).

 

Languages: English and German (reading, writing, pronunciation – excellent)

Additional Educational Trainings

  • Course of „Good Clinical Practice“ at Medical Faculty Sarajevo, University of Sarajevo, 2008 (5 CME credits).
  • DAAD (German Academic Exchange Service) research stipends at research laboratory, Clinic and Policlinic for Gyneacology, University Hospital Hamburg - Eppendorf, Germany, 2009.
  • 2nd South Eastern European Immunology Summer School under the sponsorship of EFIS (European Federation of Immunological Societies) and IUIS (International Union of Immunological Societies) 2010, Dubrovnik, Croatia.
  • Managerial-business skills development for researchers (MBSDr) program, Platform for trans-Academic Cooperation in Inovation (PACINNO), EU/AdriaticIPA project, Dec.2014- May 2015, Slovenia

REFEREED JOURNAL ARTICLES

  • Štefatić, M. Riederer, M. Balić, N. Dandachi, S. Stanzer, B. Janesch, M. Resel, D. Ler, H. Samonigg,T. Bauernhofer, Optimization of diagnostic ELISA - based tests for the detection of auto-antibodiesagainst tumor antigens in human serum, Bosn J Basic Med Sci 2008 Aug;8(3):245-50.
  • L. Kapur, N. Pojskic, J. Ramic, J. Krehic, N. Pojskic, D. Stefatic, L. Oruc. Is psychosis correlated with differential HSP90 expression? European Journal of Human Genetics 16/2 (2008):344.
  • J. Šutković, D. Ler, M.R. Abdel Gawwad. In vitro Production of Solasodine Alkaloid in Solanum nigrumunder Salinity Stress. J Phytol 2/3 (2011): 3(1):43-49.
  • Ler D., Milde-Langosch K., Kapur-Pojskic L., Bajrovic K. Extracellular catalytic subunit expression of the cAMP-dependent protein kinase A in human mammary carcinoma cells. Period biol (2012)   114/1:76.
  • Nurdan Kelesoglu, Daria Ler, Dimitar Efremov, Mirza Suljagic. Loss of PHLPP1 tumor suppressor enhances Bcr-induced pro-survival signaling in chronic lymphocytic leukemia. Period biol (2012) 114/1:15

WRITTEN BOOKS

  • D. Ler, M. Riederer. Establishment of diagnostic test for the detection of tumor markers, 2010, Germany, ISBN 978-3-639-23879-2

ARTICLES IN REFEREED CONFERENCE PROCEEDINGS

  • D. Štefatić, M. Riederer, M. Balić, N. Dandachi, S. Stanzer, B. Janesch, M. Resel, D. Ler, H. Samonigg, T. Bauernhofer, Optimization of diagnostic ELISA - based tests for the detection of auto-antibodies against tumor antigens in human serum, International Scientific Symposium, 11.Oct.2008., Tuzla, Bosnia and Herzegovina.
  • D. Ler, Proteomic approach for indirect quantification of breast cancer antigens in human serum. 2. EFIS-EJI South Eastern European Immunology School (SEEIS 2010), 1-4th October 2010, Dubrovnik, Croatia.
  • Ler D., Ramić J., Lojo-Kadrić N., Kapur Pojskić L. Expression analysis of cAMP-dependent protein kinase A (PKA) using molecular-genetic approach. Book of Abstracts (in printing), Molecular genetics research today and its application possibilities, The Second International Scientific Symposium, October 2010, Tuzla, Bosnia and Herzegovina.
  • Ler D., Ramić J., Lojo-Kadrić N., Bajrović K., Kapur Pojskić L. Molecular-genetic characterization of expression of cAMP-dependent protein kinase A (PKA), as potential molecular biomarker in early breast cancer detection. 1st Genetics Symposium in B&H; poster session: genetics in biomedicine; 17-18th February 2011, Sarajevo, Bosnia and Herzegovina.
  • Ler D., Lojo-Kadrić N., Ramić J., Milde-Langosch K., Bajrović K., Kapur Pojskić L. Protein analysis of expression of cAMP-dependent protein kinase A (PKA), potential molecular biomarker in early breast cancer detection. 1st Genetics Symposium in B&H; presentation session: genetics in biomedicine; 17-18th February 2011, Sarajevo, Bosnia and Herzegovina.
  • Radić K., Ramić J., Ler D., Bajrović K., Kapur-Pojskić L. Frequency of HPV genotypes and their correlation with general biological parameters - preliminary results. 1st Genetics Symposium in B&H; poster session: genetics in biomedicine; 17-18th February 2011, Sarajevo, Bosnia and Herzegovina.
  • D. Ler, K. Milde-Langosch, L. Kapur-Pojskić. Analysis of expression of cAMP-PKA in human breast cancer cells. 4. EFIS-EJI South Eastern European Immunology School (SEEIS 2012), 20-23rd September 2012, Igman-Sarajevo, Bosnia and Herzegovina.

ARTICLES IN CONFERENCE BOOK OF ABSTRACTS

  • D. Štefatić, M. Riederer, T. Bauernhofer. Optimization of diagnostic ELISA - based tests for the detection of auto-antibodies against tumor antigens in serum of patients with colorectal cancer. Poster session: New Technologies in Immunology, 2nd European Congress of Immunology, 13-16th September 2009, Berlin, Germany.
  • D. Ler, J. Ramić, N. Lojo-Kadrić, K. Milde-Langosch, K. Bajrović, L. Kapur-Pojskić. Expression and prognostic value of cAMP-dependent protein kinase A (PKA) as molecular biomarker in breast cancer. 11th Croatian Biological Congress with international participation; session: cell biology and genomics; 16-21th September 2012, Šibenik, Croatia.
  • Radić K., Ramić J., Ler D., Lojo Kadrić N., Pojskić N., Bajrović K., Kapur Pojskić L. Evaluation of self-sampling in a small-scale study as an alternative option in molecular-genetic HPV detection and cervical cancer screening. XXIII Balkan medical week, 21-23rd September 2012, Niš, Serbia.

ORGANIZED CONFERENCES

  • Assistant coordinator of the 5th World Water Forum (WWF) – Regional Process, 16-17th April 2008, Sarajevo, Bosnia and Herzegovina.
  • 13th Golden Helix Pharmacogenomics Symposium, IUS, May 2014, Sarajevo, Bosnia and Herzegovina.

Membership 

  • Croatian Immunological Society (HID)
  • Genetic Association in Bosnia and Herzegovina (GENuBiH)

Research interests:

Biomedical basic research in fields of oncology, pathology and molecular diagnostics

Molekular biomarkers

Immunogenetics

Projects:

Ongoing: 

“Mye-EUNITER- European Network of Investigators Triggering Exploratory Research on Myeloid Regulatory Cells”. COST Action BM1404,EU, Sept.2014-2018. 

“Molecular genetic analysis of metastasis associated in colon cancer 1 (MACC1) in Leukemia”. Research project in collaboration with INGEB Sarajevo, B&H, 2014/15.

“Correlation of MACC1 and c-Met expression in HeLa+18 cells and infection with HPV16/18”. Research project in collaboration with Institute for Biomedical Diagnostics and Research “NALAZ“, Sarajevo, B&H, 2014- present.

“Expression and prognostic relevance of MACC1 in breast cancer cells”.  Research project in collaboration with research laboratory at clinic for gyneacology, University Clinic Hamburg-Eppendorf (UKE), Germany, 2013- 2016.                               

 Accomplished:

Summer school of innovation” - geekFEST2013. Project at International University of Sarajevo, Jun-Jul 2014

„HPV-genotyping; Standardization of new specific genotyping test, using multiplex PCR for detection of HPV infection. Research project at INGEB Sarajevo, B&H, 2010 – 2013. 

„Expression and potential prognostic value of cAMP-dependent PKA (protein kinase A) as molecular biomarker in human mammary carcinomas“. Research project at INGEB, Human genetics laboratory, Sarajevo, B&H, in collaboration with research laboratory at clinic for gyneacology, University Clinic Hamburg-Eppendorf (UKE), Germany, Jan. 2009- Jun. 2011. 

 

„Establishment of diagnostic, ELISA-based test for the detection of new tumor antigens and auto-antibodies against tumor antigens in human serum“. Research project at Center for Basic Medical Research, Institute for Internal Medicine, Department of Oncology, National University Clinic in Graz, Austria (ZMF-LKH Graz), Sept.2006 – Oct. 2007. 

 


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